4-AcO-DMT Vendor online or O-Acetylpsilocin, 4-high-temperature-DMT, or Psilacetin: psychedelic tryptamine. 4-AcO- DMT – acetylated form of psilocybin fungi alkaloid psilocin and lower homologue 4-AcO-DET, 4-AcO-MIPT and 4-AcO-DIPT. The chemical was developed by David Nichols as an alternative to psilocybin for pharmacological studies, as they are both considered prodrugs of psilocin. Structural similarities with psilocybin and psilocin results in a profile with an identical subjective effect and the three compounds feel no different from each other. This allows 4-AcO- DMT as an ideal substitute for psilocybin fungi.4-AcO- DMT
It is believed that 4-AcO-DMT psychedelic effects come from its effectiveness on the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they lead into the Psychedelic experience continues to be elusive.
In the body, 4-AcO-DMT / psilacetin is thought to be deacetylated in psilocin during the first pass of the metabolism and subsequent passes through the liver (obviously as psilocin is also active when injected). This has not been proven formally, however, on the basis of reports that most users can not tell the difference between these two compounds when they enter the body to the point that they are often viewed as being no different from each other in terms of their subjective consequences. There are, however, claims of subjective differences in strength between acetylated and non-acetylated forms of psilocin.Some users report that 4-AcO-DMT lasts a little longer than psilocin while the other report, it lasts for a significantly shorter time. Many users report less body weight and nausea, compared to psilocin. Some users believe that the visual distortion of the production of 4-AcO- DMT more closely resembles those produced by DMT than psilocin. These differences may be possible if 4-AcO-DMT itself, and not just as a pro-drug.